Howard S. Young, PhD
Howard Young is a Professor at the University of Alberta in the Department of Biochemistry. His research is focused on disorders of membrane transport, covering a broad range of pathologies including heart disease and muscle wasting diseases. He is also an expert in structural biology, with an emphasis on determining protein function using X-ray crystallography and cryogenic electron microscopy (cryoEM). His team has helped solve the structures of 14 antiviral derivatives bound to the SARS-CoV-2 main protease, the first of which is currently being developed for human clinical trials.
Publications
- The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism
- A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (Mpro) of SARS-CoV-2 and MERS-CoV