Research & Training

Focus Areas & Highlights

The research interests of the Li Ka Shing Institute of Virology members encompass viral pathogenesis, vaccine development, correlates of immunity, enhancement of vaccine efficacy, oncolysis, and development of novel antivirals, with expertise in (but not limited to):

  • Adenoviruses
  • Influenza viruses
  • Pox viruses
  • Hepatitis B and C viruses
  • Rubella virus
  • Herpesviruses
  • West Nile virus
  • Dengue virus
  • Human Immunodeficiency Virus
  • Flaviviruses
  • Respiratory syncytial virus
  • Reovirus
  • Zika virus

The ultimate focus of virus research would be to develop new classes of drugs that viruses cannot develop resistance against and, ideally, drugs that would work against many different viruses, including new ones as they arise. The University of Alberta has been assembling the personnel, infrastructure and strategies needed to pursue these ambitious goals. As one of the leading centres for virology and immunology in Canada, the U of A also continues to be dedicated to the study of how viruses infect cells and cause disease, and how virus infections can be prevented with vaccines.

The LKSIoV researchers have been investigating a number of viruses and the human immune response to infection. Our scientific team hold numerous grants, have published extensively, and are cited often by their peers.

LKSIoV Research Data 1

Immunofluorescent image of HCV-infected Huh7.5 cells stained with anti-NS5a (red), anti-tubulin (white), bodipy (green), nuclei (blue). Image courtesy of Karyn Berry-Wynne (Tyrrell Research Lab)

LKSIoV Research Data 2

Left image: Hepatic tissue of a non-HCV infected mouse stained with Masson trichrone (light blue).
Right image: Hepatic tissue of a HCV-infected mouse stained with Masson trichrone (light blue), indicative of fibrosis development. Image courtesy of Suellen Lamb (Tyrrell Research Lab)