Postdoctoral Fellow and Graduate Student with Dr. Toshifumi Yokota: Neuromuscular Diseases

The laboratory of Dr. Toshifumi Yokota invites applications for postdoc, undergraduate and graduate student positions.

By utilizing integrative experimental and computational approaches, such as antisense oligonucleotides, CRISPR/Cas9, and machine-learning, the focuses of his group are to develop novel molecular therapies for neuromuscular and musculoskeletal diseases. These new methods are applied to the correction of genetic mutations, new disease models, drug discovery, and addressing fundamental biological questions.

His group is actively collaborating with the world-class researchers and industry partners. The highly interdisciplinary and collaborative environment provides unique career development opportunities for trainees. His laboratory is renowned internationally for its work on the development of genome-editing/antisense technology as well as the studies on animal models.

Full-time graduate students receive a stipend guaranteed to be equal to or greater than the minimum, determined yearly by the graduate committee (approximately $24,000-25,000/year). Priority will be given to those who want to further pursue PhD degree.

Representative original research publications of the PI with trainees since 2016 include;

Representative original research publications of the PI with trainees since 2016 include;
1. Lim et al (2020) Mol Ther (IF=8.986). In Press
2. Lim et al (2020) PNAS (IF=9.580). 117:16509-16515.
3. Echigoya et al (2019) Mol Ther. 27:2005-2017
4. Lim et al (2019) Mol Ther. 27:76-86
5. Lee et al (2018) Mol Ther Nucleic Acids.13:596-604 (IF=7.032)
6. Lee et al (2018) PLoS ONE.13:e0197084 (IF=3.057)
7. Echigoya et al (2017) PNAS:114:4213-8
8. Echigoya et al (2017) Mol Ther. 25:2561-2572
9. Touznik et al (2017) Sci Rep. 7:3672 (IF=4.259)
10. Kamaludin et al (2016) Hum. Mol. Genet. 25:3798-3809 (IF=6.393)
11. Rodrigues et al (2016) Sci. Rep. 6:38371

Each trainee receives training in a variety of areas, acquiring a basic skill set they need to further their individual projects. These skills include in silico drug design, muscle cell culture (human and animal cells), animal models (mice, dogs, and pigs), muscle physiology (e.g. exercise studies, grip strength, and muscle force measurement), histology, confocal/two-photon laser microscopy, molecular analysis (e.g. RNA-seq, quantitative real-time reverse transcription PCR analysis, molecular cloning), protein biochemistry, and proteomics analysis. This will ensure successful academic research careers and/or other career paths in non-academic health-related fields.

Past trainees have landed faculty positions in research universities (e.g. Nihon University, University of Vermont) and jobs in the life science industry (e.g. Eli Lilly, Chugai Pharmaceutical ).

Located in Edmonton, one of the sunniest cities in Canada, the Faculty has been internationally recognized as among the world’s top 50 medical schools and as one of Canada’s premier health-education institutions. The University is currently home to 39,000 students and 15,000 faculty and staff.

All applicants should have good spoken and written communication skills in English. Interested applicants should send i) a cover letter briefly describing your previous experience and your future research interest/plan, ii) a curriculum vitae, and iii) contact information of at least three references to Dr. Toshifumi Yokota (

Department of Medical Genetics 
Maternal and Child Health Scholarship Program (MatCH Program) 
Neuroscience and Mental Health Institute (NMHI)


Jan 2021