2023 Undergraduate Summer Studentship

Portrait of Alisha Duggal
Bio info of Alisha Duggal

 

Project title:  Understanding how immune signals influence the growth of intestinal tumors

How would you describe your research project to someone without a scientific background?

My research project aims to better understand the role of the immune system in the growth of colorectal cancers, which are often caused by mutations in a specific gene called Adenomatous Polyposis Coli or APC. I want to figure out which types of cells in the intestine contribute to the immune response that can either promote or suppress tumor growth. I will be using the vinegar fly, Drosophila melanogaster, as a model organism as it has similar genetics and cellular composition to the human intestine. By manipulating specific immune functions in the fly gut, I hope to identify potential targets for immune therapies that could improve patient outcomes.

What impact do you hope this project makes once completed?

The overall goal this is to gain better understanding of the cellular and molecular mechanisms that underpin colorectal cancer development, as well as the function of the immune system in this process. This understanding may aid in the creation of more effective immune-based medicines for the treatment of colorectal cancer, thereby improving patient outcomes and quality of life. These findings may impact immunotherapy targets in the treatment of this deadly illness.

How will the support from Li Ka Shing Institute of Virology help you?

I really appreciate the support from Li Ka Shing Institute of Virology in aiding my project. I will be able to perform more deep and comprehensive experiments, while expanding my knowledge in the fields of virology and immunology. This assistance will be crucial in allowing me to attain my research objectives and contribute to the progress of immunological research.

What is it about your field of study that speaks to you?

I have always been fascinated by the intricacy of the human body and how it fights disease. I first learned about immunology in my Grade 8 science class, and since then, I have been captivated by the complex system of cells, chemicals, and organs that work together to keep us healthy. The more I learn, the more astounded I become at the amazing ways in which the immune system can adapt to emerging threats and protect us from harm. 

What is a weird pet peeve you have?

I wouldn't say that this is a weird pet peeve, but it's definitely annoying when a group of people are walking really slowly in a hallway, making it difficult to pass by them.

What is one thing you cannot live without?

It would definitely be my AirPods; they are always the first thing I grab when I leave my house.

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