Fatima Mraiche

mraiche,-fatima-pic.jpg

Dr. Fatima Mraiche
Associate Professor

Education:
BSc, University of Alberta (2004)
PhD, University of Alberta (2010)

Contact Information:
Office: 9-43 Medical Sciences Building
Email: mraiche1@ualberta.ca

Research: Investigate the role of transporters including the Na+/H+ exchanger isoform 1 and sodium glucose co-transporters (SGLT), the mitogen activated protein kinase pathway (specifically p90 ribosomal S6 kinase) and the extracellular matrix in the context of cardiovascular disease and lung cancer. Innovative in educational research; advancing curricular and instructional design, processes and assessment.

Research Interests:

Understanding the molecular signaling pathways associated with the pathogenesis of cardiac remodeling, fibrosis and heart failure with a focus on the below contributing factors. Studies from our research laboratory have identified the importance of NHE1 and p90 ribosomal S6 kinase (RSK) in cardiac remodeling.
  • Electroneutral ion exchanger: Na+/H+ exchanger isoform 1 (NHE1)
  • Kinases: RSK
  • Extracellular matrix: Metalloproteinases, cathepsins, osteopontin
  • Inflammatory mediators: CD44
  • Sodium–Glucose Co-Transporters (SGLT1/SGLT2)
Understanding the signaling pathways associated with the progression of lung adenocarcinomas with a focus on the below contributing factors. Studies from our research laboratory have identified the importance of p90 ribosomal S6 kinase (RSK) in the progression of lung adenocarcinoma and its potential as a therapeutic target.
  • Kinases: RSK
  • Combination therapy: RSK inhibitors in the presence of platinum based chemotherapeutic drugs
  • Use of novel nanoparticles to deliver RSK inhibitors and other available drugs such as platinum based chemotherapeutic drugs

Scholarship of teaching and learning; advancing curricular and instructional design, processes and assessment.

Select Publications:

  1. Gorachinov F, Mraiche F, Moustafa DA, Hishari O, Ismail Y, Joseph J, Crcarevska MS, Dodov MG, Geskovski N, Goracinova K. Nanotechnology – a Robust Tool for Fighting the Challenges of Drug Resistance in Non-Small Cell Lung Cancer. Beilstein Journal of Nanotechnology (2023); 14, 240-261. https://doi.org/10.3762/bjnano.14.23.
  2. Abdulrahman N, Ibrahim M, Joseph JM, Elkoubatry HM, Al-Shamasi A, Rayan M, Ahmed R, Eldassouki H, Hasan A, Mraiche F. Empagliflozin Inhibits Angiotensin II Induced Hypertrophy in H9c2 Cardiomyoblasts Through Inhibition of NHE1 Expression. Molecular and Cellular Biochemistry. 2022 March; 477,1865–1872. doi: 10.1007/s11010-022-04411-6.
  3. Riaz S, Abdulrahman N, Uddin S, Jabeen A, GAdeau AP, Fliege L, Mraiche F. Anti-Hypertrophic Effect of Na+/H+ Exchanger-1 Inhibition is Mediated by Reduced Cathepsin B. European Journal of Pharmacology 2020 Dec 5; 888:173420. doi: 10.1016/j.ejphar.2020.173420.
  4. Abdulrahman N, Siveen KS, Joseph JM, Osman A, Yalcin HC, Hasan A, Uddin S, Mraiche F. Inhibition of p90 Ribosomal S6 kinase Potentiates Cisplatin Activity in A549 human Lung Adenocarcinoma Cells. J Pharm Pharmacol. 2020 Nov; 72(11):1536-1545. doi: 10.1111/jphp.13335.
  5. Abdulrahman N, Jaspard-Vinassa B, Fliegel L, Jabeen A, Riaz S, Gadeau AP, Mraiche F. Na+/H+ Exchanger Isoform 1 Induced Osteopontin Expression Facilitates Cardiac Hypertrophy Through p90 Ribosomal S6 Kinase. Physiological Genomics. 2018 May; 50(5): 332-342. doi:10.1152/physiolgenomics.00133.2017.
  6. Adbulrahman N, Jaballah M, Poomakkoth N, Riaz S, Abdelaziz S, Issa A, Mraiche F. Inhibition of p90 Ribosomal S6 Kinase Attenuates Cell Migration and Proliferation of the Human Lung Adenocarcinoma Through Phospho-GSK-3ß and Osteopontin. Molecular and Cellular Biochemistry 2016 July; 418(1): 21-9. doi: 10.1007/s11010-016-2727-9.
  7. Jaballah M, Mohamed IA, Almerayat B, Al-Sulaiti F, Milh M, Mraiche F. p90 ribosomal S6 kinase Modulates NHE1 Induced Cardiac Hypertrophy via GATA-4. PLoS One 2015 Apr; 10(4): e0122230. doi: 10.1371/journal.pone.0122230.

Educational Research:

  1. White PJ, Guilding C, Angelo T, Kelly JP, Gorman L, Tucker SJ, Fun A, Han J, Chen G, Samak Y, Babey AM, Caetano FA, Sarangi SC, Koenig J, Hao H, Goldfarb J, Karpa K, Vieira L, Restini C, Cunningham M, Aronsson P, Kelly‐Laubscher R, Hernandez M, Rangachari PK, Mifsud J, Mraiche F, Sabra R, Piñeros O, Zhen X, Kwanashie H, Exintaris B, Karunaratne N, Ishii K, Liu Y. Identifying Core Concepts of Pharmacology Education; A Global Initiative. British Journal of Pharmacology (2022). https://doi.org/10.1111/bph.16000.
  2. Osman A, Al-Badriyeh D, Hussain FN, Riaz S, Elewa H, Mraiche F. The Design and Implementation of an Undergraduate Health Professional Degree Elective Course on Scientific Writing, Peer Assessment and Critical Appraisal. Currents in Pharmacy Teaching and 2022 May; 14 (6), 765-772. doi: 10.1007/s40670-022-01532-x.
  3. Ali R, Alnaimi SJ, Abdulrahim S and Mraiche F. Developing Leadership Skills in Pharmacy Education. Medical Science Educator. 2022 April; 32(2): 533–538. doi: 10.1007/s40670-022-01532-x.
  4. Munusamy S, Osman A, Riaz S, Shaima A, Mraiche F. The Use of Socrative and Yammer Online Tools to Promote Interactive Learning in Pharmacy Education. Curr Pharm Teach Learn. 2019 Jan; 11(1): 76-80. doi: 10.1016/j.cptl.2018.09.021.
  5. Wilby KJ, El Hajj MS. El-Bashir, Mraiche F. Overcoming Pitfalls: Results From a Mandatory Peer Review Process for Written Examinations. Currents in Pharmacy Teaching and Learning. 2018 April; 10(4):423-426. doi: 10.1016/j.cptl.2017.12.015.