Holger Wille
Professor
Ph.D, Universität Hamburg (Hamburg, Germany)
Office: 780-248-1712
Lab: 780-248-1711
Fax: 780-492-9352
wille@ualberta.ca
Research:
The general focus of my work is the structure of amyloids and other disease-related, misfolded proteins. In particular, I am interested in the infectious prion protein (PrPSc) and the structure-function relationship underlying its infectious nature. In recent years, mounting evidence has implicated prion-like mechanisms in other neurodegenerative diseases such as Alzheimer's, Parkinson's, and Lou Gehrig's disease. The mechanistic similarities and their molecular underpinnings represent interesting research avenues beyond the classical prion diseases. The scope of my current experimental approaches is centered on electron microscopy, three-dimensional reconstruction approaches, X-ray fiber diffraction, and other biochemical and biophysical methods.
Selected Publications:
The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models.
Kamali-Jamil, R, Vázquez-Fernández, E, Tancowny, B, Rathod, V, Amidian, S, Wang, X, Tang, X, Fang, A, Senatore, A, Hornemann, S, Dudas, S, Aguzzi, A, Young, HS, Wille, H
PLoS Pathogens (2021) 17, e1009628
Full atomistic model of prion structure and conversion.
Spagnolli G, Rigoli M, Orioli S, Sevillano AM, Faccioli P, Wille H, Biasini E, Requena JR.
PLoS Pathogens (2019) Jul 11;15(7):e1007864. doi: 10.1371/journal.ppat.1007864. eCollection 2019 Jul.
The Structure of PrPSc Prions
Wille H, Requena JR.
Pathogens. (2018) Feb 7;7(1). pii: E20. doi: 10.3390/pathogens7010020. Review
Elucidating the structure of an infectious protein.
Zweckstetter, M, Requena, JR, Wille, H.
PLoS Pathogenss (2017) 13 Apr 13(4): e1006229.
The structural architecture of an infectious mammalian prion using electron cryomicroscopy.
Vázquez-Fernández, E, Vos, MR, Afanasyev, P, Cebey, L, Sevillano, AM, Vidal, E, Rosa, I, Renault, L, Ramos, A, Peters, PJ, Fernández, JJ, van Heel, M, Young, HS, Requena, JR, Wille, H.
PLoS Pathogens (2016) 12, e1005835.
Wan W, Wille H, Stöhr J, Kendall A, Bian W, McDonald M, Tiggelaar S, Watts JC, Prusiner SB, Stubbs G.
Biophysical Journal (2015) 108, 1548-1554.
The structure of human prions: From biology to structural models - Considerations and pitfalls.
Acevedo-Morantes CY, Wille H.
Viruses (2014) 6, 3875-3892.
Lab Members
Graduate Students
Sara Amidian
Madeleine Fleming
Vineet Rathod
Aishwarya Sriraman
Postdoctoral Fellows
Razieh Kamali Jamil
Aliza Borenshtein-Katz
Andrew Fang
Research Associate
Lyudmyla Dorosh
Xinli Tang
Jose Miguel Flores Fernandez
Technologist
Brian Tancowny
Victoria Foster
Links
Location
Office: 110C BARB
Lab: 110 BARB