Faculty
Mechanisms of cell-mediated cytotoxicity and apoptosis
Targeting the autotaxin-lysophosphatidate-inflammatory axis to improve cancer treatment
Membrane Transport in Corneal Blindness
Discovery of Novel Functions of small RNAs
Biology of matrix metalloproteinases (MMPs) in health and disease
Regulation of intracellular pH via the Na+/H+ exchanger
Mechanisms of regulation of gene expression
Investigating mammary gland biology and breast cancer
Regulation of protein phosphatases and phosphorylation
Functional proteomics and protease biology
Structural studies of membrane proteins associated with disease states
The mitochondrial respiratory chain in disease and in aging
Chemical and biochemical mechanisms of RNA processing
Endoplasmic reticulum in health and disease
Deciphering the functional architecture of molecular chaperone networks
Structural biology of signaling and trafficking
Metabolic programming in vertebrate cells
Structure and function of proteins involved in the protein ubiquitination pathway
Mechanisms of regulation of cell division
Structure, function and dynamics of muscle, prion, membrane, and antifreeze proteins
Molecular Cell Biology of Innate Immune Receptors
Structural investigations of infectious prions and other misfolded proteins
Regulation of calcium transport in heart disease
Mechanisms of cellular regulation
Three-dimensional structure of proteins; hydrolytic mechanisms of proteinases
Cyril Kay
Muscle contraction/relaxation: Protein de novo design
Ronald MacElhaney
Roles of lipids in the structure and function of biological membranes
Paul Scott
Structure and function of extracellular matrix macromolecules
Jim Stone
Neoplastic transformation of cultured cells by dominant oncogenes
Molecular and cell biology of phospholipid biosynthesis and function
Membrane protein structure and bioenergetics
Regulation of gene expression in the developing retina and in retinoblastoma
(1) Developing solution NMR for large protein complexes and membrane proteins.
(2)Targeting the cardiac troponin complex to understand and treat heart failure.
(2)Targeting the cardiac troponin complex to understand and treat heart failure.
Understand the complex interactions involved in the etiology of obesity, Diabetes and other chronic diseases
Analytical mass spectrometry (MS) for metabolomics and proteomics
Protein kinases and other cellular factors in the replication and pathogenesis of viruses and prions
Study of hepatitis B virus (HBV) and hepatitis C virus (HCV)
The use of genetically engineered "transgenic" mice to recreate and understand human neurologic disorders
Regulation of cholesterol homeostasis