People & Research

Understanding the cellular and molecular mechanisms underlying the choice between life (positive selection) and death (negative selection) in the thymus.

We study how genomic variation affects chemotherapeutic side effects in childhood cancer as well as molecular mechanisms bacteria use to subvert host immune systems.

My lab works in the broad field of Cardiac Immunopathology, focusing on the complex relationship between the heart and the immune system.

Investigating how gut bacteria can drive inflammatory bowel diseases. We also study the spread of antibiotic resistance across bacterial communities

We use biochemical and molecular-genetic methods to investigate mechanisms of poxvirus recombination and its linkage to replication.

We study innate immunity and intestinal inflammation.

I am interested in medical education and have developed Brainspan, a multiplayer asynchronous game generator for creating learning games

We study key viral proteins using biochemical and genetic techniques to understand their mechanisms and facilitate knowledge-based drug design.

Bioinformatics analysis of protein structures, sequence data (including high throughput sequencing), and phylogeny.

Hepatitis C & B vaccinology, virology and immunology. Investigations into the viral etiology of inflammatory disease.

Lymphocyte signalling; abnormal signalling in lymphoma; virus-host interactions in lymphocytes; protein ubiquitylation.

Respiratory viruses - We investigate the receptor binding and signalling events that occur during respiratory syncytial virus (RSV) infection in the lungs.

I manage the Faculty of Medicine and Dentistry's Cell Imaging Centre, a core imaging facility and provide microscopy expertise and resources for research staff.

Regulation of cytotoxic T lymphocyte (CTL) and natural killer (NK) cell destruction of virally infected cells and cancer cells. Role of class I MHC in these processes.

We study Cytotoxic T lymphocyte (CTL) activation in response to antigen stimulation to facilitate knowledge-based manipulation of CTL to enhance protective immunity.

Research in my laboratory is currently focused on understanding how various viral and cellular proteins impact reovirus replication in cancer cells.

Molecular genetics of mammalian nuclear DNA viruses; control of viral and cellular gene expression; cellular antiviral defence mechanisms.

My lab studies adaptive immune cell function and immunometabolism. We use genetic and diet models to understand how obesity impacts immune function.

Molecular biology of hepadnaviruses. Animal models for hepatitis B & C. Chemo- and Immunotherapy for chronic hepatitis B & C.