Academic Faculty

LacyPaigeWEB1283202526

Paige Lacy, PhD

Professor

Medicine & Dentistry

Medicine

About Me

I obtained my PhD from the University of Otago, New Zealand in 1992 after completing a BSc (Hons) in Physiology and Biochemistry in Victoria University of Wellington, New Zealand, in 1986. My first postdoctoral fellowship was awarded by The Wellcome Trust/Health Research Council of New Zealand in 1992 at the University College London in the UK for 2 years, and then the Department of Medicine, Wellington School of Medicine, New Zealand for another 2 years. I was awarded a Parker B. Francis Pulmonary Fellowship in 1998 at the University of Alberta, where I joined as a faculty member in 2000. I also received a CIHR New Investigator award in 2001. In 2009-2010, I was an Alberta Heritage Foundation for Medical Research (AHFMR) visiting speaker at the Institute for Molecular Bioscience (IMB), University of Queensland, Australia, for her sabbatical. I am currently the Director of the Pulmonary Research Group in the Faculty of Medicine & Dentistry.

In my spare time, I enjoy cycling and walking along Edmonton's river valley, golfing when my husband drags me out to the golf course, and occasionally playing squash. I travel frequently to Vancouver to visit colleagues and my daughter and her fiance, as well as New Zealand to visit with colleagues and my family.


Research

Protein trafficking in immune cells

My areas of research interest are focused on molecular and cellular mechanisms that regulate inflammatory responses in allergy, asthma, and lung diseases. Together with my trainees and collaborators, we have helped to advance our understanding of how inflammatory mediators are released by immune cells including eosinophils, neutrophils, macrophages, and mast cells. I have a specific interest in understanding mechanisms of cytokine and chemokine secretion from innate immune cells.

Metabolomics of welding fume exposure

Recently, we have initiated a new study on the feasibility of using metabolomics analysis in determining potential biomarkers of welding fume exposure. This study involves the analysis of urine samples from welding apprentices based at NAIT. My interest in metabolomics grew from the potential to discover markers of inflammation in body samples, and we have determined that metabolomics analysis may discriminate between healthy and pneumonia-infected individuals. We are currently determining if exposure to welding fumes may alter the metabolic profile of urine samples in apprentices that are enrolled in the welding program at the Northern Alberta Institute of Technology, Edmonton, AB.


Teaching

I am currently mentoring graduate students and postdoctoral fellows. I am available to mentor additional students and am accepting applications from appropriate individuals that have Canadian permanent residency or citizenship.