Academic Faculty

GJ-Picture

Glen Jickling, MD MSc FRCPC

Assistant Professor

Medicine & Dentistry

Medicine

About Me

Glen Jickling has a strong interest in vascular neurology, including ischemic stroke and hemorrhagic stroke. Dr. Jickling’s research focuses on the role of the immune system in cerebrovascular disease including patterns of gene expression and epigenetic regulation. He has described RNA markers in blood as a method to distinguish stroke subtypes and predict cause in strokes of unclear etiology. Dr. Jickling is on the editorial boards of several journals.


Education and Training:

1995             H. BSc, Biochemistry, University of Calgary, Calgary, Canada

2000-2003    MD, University of Alberta, Edmonton, Canada

2005-2008    Resident, Neurology, University of Alberta Hospital, Edmonton AB Canada

2009-2011     MSc, Clinical Research, University of California Davis, California USA


Academic Appointments:

2013-2016    Assistant Professor, Department of Neurology, University of California Davis

2014-2016    Director Stroke Program, Department of Neurology, University of California Davis

2016-P         Assistant Professor, Division of Neurology, University of Alberta, Edmonton, Canada


Hospital Appointments:

2016-P       AH Owen Stroke Prevention Clinic, University of Alberta Hospital, Edmonton, Alberta





Research

Research Projects:

  • Biomarker research program, Dr. Jickling is working on RNA-based tests to diagnose whether a person has had a stroke or transient ischemic attack and to predict the cause of stroke.
  • How does the immune system contribute to risk of stroke and brain injury?


Select Publications:

Peer-Reviewed Original Research (trainees directly supervised by me are underlined):

18. *Jickling GC, Zhan X, Ander BP, Turner RJ, Stamova B, Xu H, Tian Y, Liu D, Davis RR, Lapchak PA, Sharp FR. Genome response to tissue plasminogen activator in experimental ischemic stroke. BMC Genomics 2010; 11:254. PMID: 20406488

23. *Jickling GC, Xu H, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Turner RJ, Mesias M, Verro P, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Signatures of cardioembolic and large-vessel ischemic stroke. Annals of Neurology 2010; 68(5):681-92. PMID: 21031583.

32. *Jickling GC, Sharp FR. Blood biomarkers of ischemic stroke. Neurotherapeutics 2011;8(3):349-60. PMID 21671123.

33. *Jickling GC, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Johnston SC, Verro P, Sharp FR. Profiles of lacunar and non-lacunar stroke. Annals of Neurology 2011; 70:477-485. PMID: 21796664.

34.*Jickling GC+, Zhan X+ (+Co-first authors), Tian Y, Stamova B, Xu H, Ander BP, Turner RJ, Mesias M, Verro P, Bushnell C, Johnston SC, Sharp FR. Transient ischemic attacks characterized by RNA profiles in blood. Neurology 2011; 77(19):1718-24. PMID: 21998319.

44. *Jickling GC, Zhan X, Stamova B, Ander BP, Liu D, Sison S, Verro P, Sharp FR. Prediction of cardioembolic, arterial and lacunar causes of cryptogenic stroke by gene expression and infarct location. Stroke 2012; 43(8):2036-41. PMID: 22627989

45. *Jickling GC, Zhan X, Stamova B, Ander BP, Tian Y, Liu D, Sison S, Verro P, Johnston SC, Sharp FR. Ischemic Transient Neurological Events Identified by Immune Response to Cerebral Ischemia. Stroke 2012; 43(4):1006-12. PMID: 22308247.

50. *Jickling GC, Ander BP, Stamova B, Zhan X, Liu D, Rothstein L, Verro P, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke. Annals of Neurology 2013; 74(2):232-40. PMID: 23468366.

52. *Jickling GC, Liu D, Stamova B, Ander BP, Zhan X, Lu A, Sharp FR. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab 2014; 34(2):185-99. PMID: 24281743. 

63. *Jickling GC, Ander BP, Zhan X, Stamova B, Noblett D, Liu D. microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. PLoS One 2014; 9(6): e99283. PMID: 24911610.

69. *Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR. Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab. 2015; Jun;35 (6):888-901 PMID: 25806703.

73. *Jickling GC, Ander BP, Shroff N, Orantia M, Stamova B, Dykstra-Aiello C, Hull H, Zhan X, DaZhi Liu D, Sharp FR. Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke. Neurology 2016; 87(21):2198-2205.