DanielBarreda01

Daniel Barreda

Professor (Joint with BIOSCI)

Agricultural Life and Environmental Sciences

Agricultural Food and Nutritional Science

About Me

DEGREE 

BSc, Microbiology and Biochemistry, University of Victoria

PhD, Physiology and Cell Biology, University of Alberta 

Postdoc, Medical Immunology, University of Pennsylvania

JOB/RESEARCH AREA 

Immunology

AWARDS

A. Teaching Awards

1. Inspirational Instructor Award - Interdepartmental Science Students’ Society (2012).

2. Nominated for the Faculty of Agricultural, Life & Environmental Sciences Faculty Teaching Award (2012).

3. University of Alberta Provost Award for Early Achievement of Excellence in Undergraduate Teaching (2011). This represents the most prestigious award in undergraduate teaching at the Assistant Professor level in the University of Alberta.

4. NACTA Teaching Award of Merit - North American Colleges and Teachers of Agriculture (2011).

5. Teacher of the Year Award (2008-2009)– Department of Agricultural, Food and Nutritional Science (AFNS).

6. Teacher of the Year Award (2007-2008)– Department of Agricultural, Food and Nutritional Science (AFNS).

B. Research Awards

7. Nominated for the Canadian Society of Zoology (CSZ) Bob Boutilier New Investigator Award for Excellence in Research (2012).

8. Research and Innovation Award - Faculty of Agricultural, Life and Environmental Sciences (2011) for outstanding research contributions by a new faculty member.

9. Nominated for the NSERC Doctoral Prize for Research Excellence in Natural Sciences and Engineering (2004).

10. Nominated for the Governor General’s Gold Medal - Most Outstanding Doctoral Student at the University of Alberta (2003).

11. Banff Inflammation Workshop Young Investigator Prize (2003).

12. Alan Birdsall Memorial Scholarship: Research in Applied Fisheries Ecology & Management (2002).

13. Andrew Stewart Memorial Graduate Prize for Research Excellence (2000).

C. Scholarships and Travel Awards

14. ICI/FOCIS International Congress of Immunology Travel Award (2004).

15. NSERC Postdoctoral Fellowship (2003).

16. International Society of Developmental and Comparative Immunology (ISDCI) Travel Bursary (2003).

17. Mary Louise Imrie Graduate Student Award (2003).

18. Department of Biological Sciences Travel Award (2003).

19. University of Alberta Dissertation Fellowship + tuition/fees (2002).

20. Fisheries and Oceans Canada (DFO) Postgraduate Scholarship (2001).

21. NSERC PGS-B Scholarship (2000).

22. Walter H. Johns Graduate Fellowship (1998; 1999; 2000; 2001).

23. NSERC PGS-A Scholarship and increased stipend and Intersession Bursary (1998).

24. Graduate Teaching Assistantship (1997).

25. Walter H. Johns Tuition Scholarship (1997).

26. Faculty of Science GTA Scholarship (1997).

27. President’s Entrance Scholarship (1992).

28. Canada Scholarship – McGill University (1992 - declined).

29. B.C. Provincial Scholarship (1992).


Research

Current Research Interests                                                                               

My laboratory is interested in the evolution of leukocyte immune defense mechanisms. Broadly, we research questions in the areas of innate immunity, phagocytosis, inflammation, host-pathogen interactions, and zoonosis. My research program includes both fundamental and applied studies in topics affecting human and veterinary medicine. I hold appointments in the Department of Biological Sciences, and the Department of Agriculture, Forestry, and Nutritional Science at the University of Alberta. Currently, we are focusing our efforts on:

1) Evolution of control mechanisms for inflammation:
Our long-term objective is to dissect the contributions of phagocytes as effectors and regulators of inflammation through evolution, and to understand the implications of these evolving roles to health and disease. We focus on the balance between pro-inflammatory and homeostatic responses at infection sites because of its relevance to host immunocompetence and disease prevention. Characterization of well-conserved pathways offers important evolutionary context for generation of the complex immune networks that now exist in higher vertebrates. Moreover, characterization of more recently developed features may help identify vulnerability gaps that allow for pathogen infiltration or which contribute to unwanted immune reactions (e.g. autoimmunity).

Representative projects:
a) Evolution of phagocyte responses to pathogens and homeostatic stimuli at infection sites
b) Contributions of a novel soluble CSF-1 receptor to innate antimicrobial responses across evolution
c) Divergent roles of macrophages and neutrophils in the induction and control of inflammation

2) Comparative immunology approaches for assessment of animal and environmental health: These correspond to cross-disciplinary projects that take advantage of academic-industry-government linkages to address relevant issues in animal and environmental health. The immunity aspect provided by my lab coupled to veterinarian support ensures that industry desirable outcomes (e.g. reduction in livestock methane reduction, increased bone strength, shifts in gut microflora composition) are not associated with negative changes in immunity and health. In other projects, our comparative models are also being used as bioindicators of environmental health (e.g. changes to fish immunocompetence following remediation of industrial effluents).

Representative projects:
a) Targeted disruption of rumen methanogen activity for reduction of greenhouse gas emissions.
b) Modulation of swine immunity and health in response to vitamin D metabolites.
c) A non-antibiotic nutritional immunomodulator to control bovine respiratory disease.
d) Safe reuse water: Assessment of the removal of chemical contaminants from reuse water using a fish biomonitoring system.

Our studies take advantage of a range of hosts that include cartilaginous and bony fish, avian and rodent animal models, as well as larger animal species that are critical to the Alberta economy. We utilize high-end techniques in flow cytometry, microscopy, cellular and molecular immunology, and protein biochemistry.

For additional information (including current postings) please refer to Barreda Lab main page at:
http://grad.biology.ualberta.ca/labs/barreda/


Teaching