Pharmacokinetics and Delivery of Xenobiotics
Dr. Davies' research program in the Faculty of Pharmacy & Pharmaceutical Sciences aims to investigate the factors that influence variability in drug response through an understanding of drug delivery (nanomedicine) and disposition (pharmacokinetics) as well as action to optimize the use of anti-oxidant and anti-cancer agents (pharmacology and toxicology). The Davies laboratory explores factors affecting the dissolution, stability, release and safety and efficacy of anti-oxidant nutraceutical and anti-cancer drugs, the role of liver and renal metabolism in determining effects of drugs, and new avenues for the treatment of hyperlipidemia, hepatitis, colorectal cancer and inflammation associated with arthropathies. Dr. Davies laboratory uses a variety of sample analyses, including atomic absorption spectrophotometry, high performance liquid chromatography, specializing in HPLC/MS analyses, including: Bioanalytical Sample Analysis, Quantitative Analysis, Pharmacokinetic Analysis, High-Throughput Drug Discovery, Analytical Methods Development and Validation, Structure Elucidation including Metabolite Identification and Stability Impurity Indentification.
More recent investigations have focused on block polymeric micelles for nano-drug delivery of hydrophobic xenobiotics and on plant secondary metabolites and metabolism and disposition of anti-inflammatory/anti-cancer nutraceuticals and phytochemicals including stilbenes and flavonoids, nutraceuticals in animal models and scaling their impact on human health. In addition target lymphatic delivery approaches to improve oral bioavailability are also being undertaken.
Over the past decade Dr. Davies has also been heavily involved in pharmacy education research including curriculum mapping, interprofessional education, online teaching, and implementing exanded scopes of practice programs