One of the great quandaries of our age is that despite all our scientific progress, our attempts to improve human lives often seems high-risk, time-intensive and expensive. The genetic code has been deciphered, thousands of genomes have been sequenced, and most protein folds are now known. However, our understanding of how dynamic organelles and living cells are formed is at its infancy, and more effective drug molecules for addressing the unmet needs of patients are ever-more costly to design and deliver.
Our lab’s ethos is team-based and collaborative, and involves international consortia and funding from across the world. We partner with industry to address global challenges including tackling novel targets and cancers lacking effective cures, we work with business to develop new products, and engage with leaders to inform policy and spur innovation.
Please let me know if you would like to work with us, I am particularly looking for motivated students, talented postdoctoral fellows, research collaborators and commercial partners.
Guix FX, Sannerud R, Berditchevski F, Arranz AM, Horré K, Snellinx A, Thathiah A, Saido T, Saito T, Rajesh S, Overduin M, Kumar-Singh S, Radaelli E, Corthout N, Colombelli J, Tosi S, Munck S, Salas IH, Annaert W, De Strooper B. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.
Mol Neurodegener. 2017 Mar 10;12(1):25.
Gräßel L, Fast LA, Scheffer KD, Boukhallouk F, Spoden GA, Tenzer S, Boller K, Bago R, Rajesh S, Overduin M
, Berditchevski F, Florin L. The CD63-Syntenin-1Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses.
Sci Rep. 2016 Aug 31;6:32337.
Lenoir M, Kufareva I, Abagyan R, Overduin M
. Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily.
Membranes (Basel). 2015 Oct 23;5(4):646-63.
Diviani D, Raimondi F, Del Vescovo CD, Dreyer E, Reggi E, Osman H, Ruggieri L, Gonano C, Cavin S, Box CL, Lenoir M, Overduin M
, Bellucci L, Seeber M, Fanelli F. Small-Molecule Protein-Protein Interaction Inhibitor of Oncogenic Rho Signaling.
Cell Chem Biol. 2016 Sep 22;23(9):1135-46.
Browning DF, Bavro VN, Mason J, Sevastsyanovich YR, Rossiter AE, Jeeves M, Wells TJ, Knowles T, Cunningham AF, Donald J, Palmer T, Overduin M
, Henderson IR (2015) Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion
, Mol Micro, 97(4):646-59
Jeeves M, L Quill, M Overduin, Structure-based Drug Design using NMR (2015) eMagRes 4, 231–240.
Kufareva I, M Lenoir, F Dancea, P Sridhar, E Rausch, C Bissig, J Gruenberg, R Abagyan, M Overduin
(2014) Discovery of novel membrane binding structures and functions
, Biochem Cell Biol, 92(6):555-563.
Knowles, TJ, DF Browning, M Jeeves, R Maderbocus, S Rajesh, P Sridhar, E Manoli, D Emery, U Sommer, A Spencer, DL Leyton, D Squire, RR Chaudhuri, MR Viant, AF Cunningham, IR Henderson, M Overduin
(2011) Structure and function of BamE within the outer membrane and the β-barrel assembly machine
, EMBO Reports 12(2):123-8.