Faculty Members

Dr. Gordon Chan

Associate Professor

Department of Oncology

Division of Experimental Oncology
    Contact details are for academic matters only.

About Me


PhD in Medical Biochemistry, University of Calgary, Alberta, Canada

supervisor: Dr. David Bazett-Jones

Post-doctoral training at the Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, USA

supervisor: Dr. Tim Yen


Teaching

Teaching
ONCOL 570, Directed Reading in Experimental Oncology, course coordinator

ONCOL 520, Tumor Biology, course coordinator

ONCOL 425, Advance Topics in Cancer Research, instructor for Module 3, Mitosis and Aneuploidy in Cancer

Research opportunities

Research training is available for undergraduate summer students, undergraduate research project students (398, 399, 498, 499 courses), undergraduate co-op students, graduate students and post-doctoral fellows. Individuals interested in graduate work in Oncology in my laboratory should have a strong background in molecular biology, biochemistry and/or cell biology, since research projects typically involve the use of platform technologies from these disciplines. Funding for students and fellows is available through application to competitive agencies (e.g., Alberta Innovates, CIHR, NSERC, Alberta Cancer Foundation, CRINA) or from operating grants to the Chan research program.



Research

We have three main areas of research: (i) the role(s) of the RZZ complex in mitotic checkpoint regulation and (ii) the role of the mitotic checkpoint in mitotic catastrophe (iii) cell cycle kinases Wee1 and Myt1 synthetic lethality in breast cancer. 

(i) The RZZ complex consists of three proteins, Rod, Zw10 and Zwilch. They are kinetochore proteins that recruit the microtubule motor, dynein/dynactin, to kinetochores but were found to be also essential for the mitotic checkpoint. The RZZ complex is essential for the recruitment of the mitotic checkpoint effector Mad2 to kinetochores. The exact mechanism is still unknown. We are using molecular, biochemical and cell biological approaches to study the structure and function of the mitotic checkpoint apparatus in order to understand the underlying mechanism. (ii) Mitotic catastrophe is a cell death phenomenon that has been observed, however, there is not a molecular marker and the mechanism of action is not known. We are following up on the findings that genotoxic treatments of cancer cells often result in checkpoint adaptation and ultimately mitotic catastrophe. We have observed that prolonged mitotic arrest and centromere fragmentation often accompany mitotic catastrophe. We are examining the role of the mitotic checkpoint in this cell death process. (iii) Wee1 and Myt1 are cell cycle kinases that mediate inhibitory Cdk1 phosphorylation. In addition to being important for regulating the G2/M checkpoint, they are also essential for inhibiting Cdk1 activity at the end of mitosis. MK-1775 is a small molecule inhibitor of Wee1 kinase activity and is currently undergoing Phase I/II clinical trial for multiple cancers. We have identified the Myt1 kinase as a resistance factor for MK-1775 in breast cancers. We are examining the mechanism of Myt1 function in mediating MK-1775 resistance.


Research Keywords

Microtubule, mitosis, drug, inhibitor, cell cycle, synthetic lethality, drug resistance mechanism

Team Members

Cody Lewis, PhD student

Joanne Smith, MSc student

Abigail Linares Cruz, MSc student

Kaushiki Roy, visiting PhD student