Dr. Elaine Leslie

Associate Professor
Department of Physiology
    Contact details are for academic matters only.

About Me

Dr. Elaine M. Leslie received her BSc in Toxicology from the University of Guelph and her PhD in Pharmacology and Toxicology from Queen’s University.  Dr. Leslie completed postdoctoral training at the National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, and at the University of North Carolina, Chapel Hill, North Carolina. Dr. Leslie began her appointment as an Assistant Professor in 2006 in the Departments of Physiology and Laboratory Medicine and Pathology at the University of Alberta, Edmonton, Alberta, Canada and is currently an Associate Professor.  Formerly, Dr. Leslie was an Alberta Innovates Health Solutions Scholar and a Canadian Institutes of Health Research New Investigator.  In 2016, Dr. Leslie was awarded the Society of Toxicology of Canada V.E. Henderson Award , an early career award for significant contributions to the science of toxicology in Canada.  Dr. Leslie was also honoured with the 2017 American Society of Pharmacology and Experimental Therapeutics Division of Toxicology Junior Investigator Award, for “excellent original research by early career investigators in the area of toxicology”.  Dr. Leslie has had a long-standing interest in the involvement of transporter proteins and conjugating enzymes in detoxification. The Leslie laboratory has made significant contributions to understanding how ATP-binding cassette (ABC) transporter proteins are involved in protecting tissues from xenobiotic induced injury. The major focus of Dr. Leslie’s research is the biotransformation and transport of the environmental human carcinogen arsenic. The Leslie lab routinely uses physiologically relevant human models (e.g., sandwich cultured primary human hepatocytes (SCHH)) in combination with heterologous expression of specific transporters.  These approaches are taken to first understand what is happening in a physiological context then to understand the molecular processes involved in regulating specific proteins.

Research Keywords

arsenic, selenium, glutathione, ABC transporters, carcinogenesis, hepatobiliary transport, cellular handling of toxicants, toxicology, glutathione S-transferase P1, fatty acylation