Faculty Members

Dr. Frank van Landeghem

Associate Professor

Department of Laboratory Medicine & Pathology

Division of Anatomical Pathology
    Contact details are for academic matters only.

About Me

Since 2013 I'm working as Associate Professor of Neuropathology at the Division of Anatomical Pathology, Department of Laboratory Medicine & Pathology, University of Alberta.

Following graduation in 1993 from the University of Münster in Germany, I was trained in Neuropathology by A. von Deimling and W. Brück at the Charité - University Medicine Berlin, Germany (1995 - 2001). From 1995-96, I worked on my doctoral thesis (Dr. med.; Title:" Macromorphological and histological findings of the larynx in sudden and unexpected infant death”, mentor: Prof. Dr. med. B. Brinkmann, Legal Medicine, Westfälische Wilhelms-Universität Münster). In 2007, I became active chair of the Institute of Neuropathology at the Charité. In December 2009, I received my habilitation („Glutamate transport in the CNS - examinations following traumatic brain injury and transient global ischemia“, mentor: Prof. Dr. med. A. von Deimling, Neuropathology, Charité, Berlin, Germany). From 2008 - 2012, I worked at the Dpt. of Neuropathology and the German Brain Tumor Reference Centre in Bonn, Germany with Torsten Pietsch and Albert Becker. In total, I performed ca. 42,000 diagnoses for biopsies/resections and ca. 13,000 neuro-autopsies, including forensic cases.

My research interests focus on neuro-oncology and neuro-inflammation. I have received grants from the University Hospital Foundation (Kaye Fund Competition 2018/19), University of Alberta, Deutsche Forschungsgemeinschaft' ('German Research Society'; DFG), and ZNS - Hannelore Kohl Stiftung ('CNS - Hannelore Kohl Foundation'). I published more than 70 papers in peer-reviewed journals.

Selected publications:

  • Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25;10(1):4343. doi: 10.1038/s41467-019-12187-5. PubMed PMID: 31554817; PubMed Central PMCID: PMC6761184.
  • Chen PA, Shrivastava G, Balcom EF, McKenzie BA, Fernandes J, Branton WG, Wheatley BM, Petruk K, van Landeghem FKH, Power C. Absent in melanoma 2 regulates tumor cell proliferation in glioblastoma multiforme. J Neurooncol. 2019 Sep;144(2):265-273. doi: 10.1007/s11060-019-03230-y. Epub 2019 Jul 6. PubMed PMID: 31280432.
  • Lau D, Cooper R, Chen J, Sim VL, McCombe JA, Tyrrell GJ, Bhargava R, Adam B, Chapman E, Croxen MA, Garady C, Antonation K, van Landeghem FKH, Ip S, Saxinger L. Mycobacterium chimaera encephalitis post-cardiac surgery: A new syndrome. Clin Infect Dis. 2019 Jun 18. pii: ciz497. doi: 10.1093/cid/ciz497. [Epub ahead of print] PubMed PMID: 31247065.
  • Das S, van Landeghem FKH. Clinicopathological Spectrum of Bilirubin Encephalopathy/Kernicterus. Diagnostics (Basel). 2019 Feb 28;9(1). pii: E24. doi: 10.3390/diagnostics9010024. Review. PubMed PMID: 30823396; PubMed Central PMCID: PMC6468386.
  • Balcom EF, Doan MAL, Branton WG, Jovel J, Blevins G, Edguer B, Hobman TC, Yacyshyn E, Emery D, Box A, van Landeghem FKH, Power C. Human pegivirus-1 associated leukoencephalitis: Clinical and molecular features. Ann Neurol. 2018 Nov;84(5):781-787. doi: 10.1002/ana.25343. Epub 2018 Nov 8. PubMed PMID: 30246885.
  • Johann PD, Hovestadt V, Thomas C, Jeibmann A, Heß K, Bens S, Oyen F, Hawkins C, Pierson CR, Aldape K, Kim SP, Widing E, Sumerauer D, Hauser P, van Landeghem F, Ryzhova M, Korshunov A, Capper D, Jones DTW, Pfister SM, Schneppenheim R, Siebert R, Paulus W, Frühwald MC, Kool M, Hasselblatt M. Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome. Brain Pathol. 2017 Jul;27(4):411-418. doi: 10.1111/bpa.12413. Epub 2016 Aug 11. PubMed PMID: 27380723.
  • Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon RE, Lipp ES, Dunham C, Hukin J, Eisenstat DD, Fulton D, van Landeghem FK, Santi M, van Veelen ML, Van Meir EG, Osuka S, Fan X, Muraszko KM, Tirapelli DP, Oba-Shinjo SM, Marie SK, Carlotti CG, Lee JY, Rao AA, Giannini C, Faria CC, Nunes S, Mora J, Hamilton RL, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognár L, Klekner A, Hortobágyi T, Leary S, Ermoian RP, Olson JM, Leonard JR, Gardner C, Grajkowska WA, Chambless LB, Cain J, Eberhart CG, Ahsan S, Massimino M, Giangaspero F, Buttarelli FR, Packer RJ, Emery L, Yong WH, Soto H, Liau LM, Everson R, Grossbach A, Shalaby T, Grotzer M, Karajannis MA, Zagzag D, Wheeler H, von Hoff K, Alonso MM, Tuñon T, Schüller U, Zitterbart K, Sterba J, Chan JA, Guzman M, Elbabaa SK, Colman H, Dhall G, Fisher PG, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro AM, Pollack IF, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins CE, Rutka JT, Dirks P, Pfister SM, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Ellison DW, Taylor MD. Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis. J Clin Oncol. 2016 Jul 20;34(21):2468-77. doi: 10.1200/JCO.2015.65.7825. Epub 2016 Jun 6. PubMed PMID: 27269943; PubMed Central PMCID: PMC4962737.
  • Hasselblatt M, Thomas C, Hovestadt V, Schrimpf D, Johann P, Bens S, Oyen F, Peetz-Dienhart S, Crede Y, Wefers A, Vogel H, Riemenschneider MJ, Antonelli M, Giangaspero F, Bernardo MC, Giannini C, Ud Din N, Perry A, Keyvani K, van Landeghem F, Sumerauer D, Hauser P, Capper D, Korshunov A, Jones DT, Pfister SM, Schneppenheim R, Siebert R, Frühwald MC, Kool M. Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis. Acta Neuropathol. 2016 Jul;132(1):149-51. doi: 10.1007/s00401-016-1574-9. Epub 2016 Apr 11. PubMed PMID: 27067307.

PubMed:

https://www.ncbi.nlm.nih.gov/pubmed/?term=van+Landeghem+F


Research Keywords

Biomarkers, Biomedical research, Infectious diseases, Neuro-Oncology, Translational research