Academic Faculty

Rachel Khadaroo, Cross Appointment, Department of Surgery

Assistant Professor

Degrees & Appointments

MD (McMaster University, Hamilton, Ontario),

PhD (Experimental Surgery/molecular/cellular biology, University of Toronto)

FRCSC (General Surgery, University of Alberta)

Critical Care Medicine Fellowship (University of Toronto)

Assistant Professor in Department of Surgery (University of Alberta)

Brief Biography

I am a surgeon, critical care medicine specialized, and scientist at the University of Alberta Hospital and an assistant professor in the Division of General Surgery. My clinical interests are in Acute Care Surgery and critical illness.

I earned my Bachelor of Science and Doctor of Medicine at McMaster University in Hamilton, Ontario. My Doctor of Philosophy was achieved in the Surgical Scientist Program at the University of Toronto with my thesis in oxidant-induced lung injury following trauma.

I completed my General Surgery training at the University of Alberta and further specialized in the area of Critical Care Medicine at the University of Toronto.

Research Interests

Intestinal Ischemia/Reperfusion injury, sepsis, lung injury, innate immunity, inflammatory cell signaling, surgical infection, acute care surgery

Brief Summary of my Research

My major research interests relate to intestinal injury and the role the intestine has in critical illness, multiple organ dysfunction, and sepsis. To accomplish our goals my laboratory has developed clinically relevant animal and cellular models.  Specifically, my lab is working on:

  1. Understand the cellular and molecular mechanisms whereby intestinal ischemia/reperfusion injury causes distant organ injury and consequent patient morbidity and mortality.
  2. Discovering unique biomarkers to better diagnosis intestinal injury
  3. Examining how these biomarkers act through intracellular signaling leading to an augmented inflammatory response
  4. Validate these biomarkers in a clinical setting and examine the role of acute intestinal ischemia/reperfusion plays in resultant multiple organ dysfunction, acute lung injury, and sepsis

Selected Publications

  1. Khadaroo RG, Marshall JC. Gastrointestinal Dysfunction in the Critically Ill: Can We Measure It? Critical Care. 12:180 Sept. 2008
  2. Powers KA, Szaszi K, Khadaroo RG, Tawadros PS, Marshall JC, Kapus A, Rotstein OD. Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages. J Exp Med. 203(8):1951-61 Aug 2006
  3. Khadaroo RG, He R, Parodo J, Powers KA, Kapus A, Rotstein OD. The role of the Src family of tyrosine kinases following oxidant induced lung injury in vivo. Surgery 136(2):483-8 Aug. 2004
  4. Khadaroo RG, Fan J, Powers KA, Kapus A, Rotstein OD. Impaired Induction of IL-10 Expression in the Lung Following Hemorrhagic Shock. Shock 22(4):333-9  Oct. 2004
  5. Khadaroo RG, Kapus A, Powers KA, Cybulsky MI, Marshall JC, Rotstein OD. Oxidative stress reprograms LPS signaling via Src kinase-dependent pathway in Raw 264.7 macrophage cell line. J Biol Chem. 278(48):47834-41, Nov. 2003
  6. Khadaroo RG, Parodo J, Powers KA, Papia G, Marshall JC, Kapus A, Rotstein OD. Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through a Src dependent pathway. Surgery, 134:212-46, Aug. 2003

Educational Activities

I will be supervising one MSc student. I am always happy to discuss the possibility of mentoring students, residents, or fellows.

Contact Details

Tel: 780-407-7728
Fax: 780-407-7674