His main research interest has been in clinical aspects of upper GI disorders. He has done numerous trials in uninvestigated and uninvestigated dyspepsia, gastroesophageal reflux disease, and gastric and duodenal ulcers. This includes many studies on Helicobacter pylori and its role in the upper GI diseases, evaluations of diagnostic tests and studies on treatment and antibiotic resistance. He has also done several trials evaluating management of functional dyspepsia and a series of management trials in uninvestigated dyspepsia in primary care. Up to January 1, 2012, he has published 194 articles in peer-reviewed journals. A special interest relates to research methodology in the conduct of dyspepsia studies. He was chair of the first ROME Committee design of clinical trials in functional GI disorders and was a committee member for the same topic in the ROME III working party on functional GI disorders.
With regard to research, Helicobacter pylori infection of the stomach continues to be a focus of interest. Together with Dr. Karen Goodman, PhD Clinical Epidemiologist in the GI Division and help from others, a comprehensive research program has been developed to look at the health consequences of Helicobacter pylori in the Canadian North. The prevalence of this infection is very height (60%) in Northern Canadian communities. This research program has been very successful in attracting peer-reviewed funding from e.g. CIHR, the Canadian Arctic Network, and local government agencies in the Northwest Territories and Yukon. An interesting component of the research program has been the ability to offer unsedated gastroscopies, which to date has taken place in two small communities: 1) Aklavik, NWT and 2) Old Crow, Yukon. These studies document the frequency of abnormalities, such as stomach ulcers and inflammation in the stomach (gastritis. By obtaining biopsies (tissue specimens taken from the stomach) this project is also able to determine how severe and extensive the inflammation is in infected individuals and for treatment to evaluate which treatment regimens are the most effective in curing the infection.