Dr. Stephane Bourque is currently appointed as Assistant Professor in the Department of Anesthesiology & Pain Medicine in the Faculty of Medicine and Dentistry.
My research interests focus on mechanisms that contribute to normal and accelerated age-related decline in cardiovascular function. My work involves two broad areas of cardiovascular pharmacology. The first focuses on mechanisms by which anesthetic agents (and other pharmacological agents) affect vascular function and blood pressure regulation; my laboratory works closely with colleagues in the Departments of Anesthesiology and Pain Medicine and Surgery to address important clinical issues (e.g. perioperative hypotension, sepsis, anemia) that impact surgical outcomes and subsequent patient recovery, particularly in the elderly. The second area focuses on mechanisms by which stressors during pregnancy alter the developmental trajectory of the fetus, which in turn influence the offspring’s susceptibility to chronic diseases in later life. The developing fetus is highly vulnerable to insults (e.g. iron deficiency, hypoxia) which can induce lasting functional changes in key organ systems that progress with time, resulting in accelerated age-related decline. By extension, targeted therapies during critical windows of development may provide protection and confer long-term health benefits to the offspring. My laboratory employs a number of strategies to understand how prenatal stressors and therapeutics impact fetal development and long-term cardiovascular health in the offspring.
Canadian Institutes for Health Research
Canadian Foundation for Innovation
Women and Children’s Health Research Institute
University Hospital Foundation
Alberta Innovates – Health Solutions
Dr Ferrante S Gragasin - Co-Investigator
Sareh Panahi - Laboratory Manager
Dr Kimberly Macala - PhD Student
Andrew Woodman - MSc Student
Stephana Cherak - MSc Student
Patrick Fung - MSc Student
Developmental programming of cardiovascular function by iron deficiency: early mechanisms and therapeutic interventions.
- Funding Source: Canadian Institutes of Health Research
- Year Granted: 2018
- Research Role: National Principal Investigator