Alberta Transplant Applied Genomics Centre

Gene Lists

Our gene lists are pathogenesis-based transcripts sets (PBTs) that were generated by using Affymetrix Microarrays. The PBTs were defined to represent the major biologic events in cellular graft rejection, cytotoxic T-cell infiltration, interferon-gamma effects and epithelial deterioration. They were derived from experimental mouse kidney transplants, cultured cells and human kidney biopsies.
 
References:
The Molecular Phenotype of Kidney Transplants. PF Halloran, DG de Freitas, G Einecke, KS Famulski, LG Hidalgo, M Mengel, J Reeve, J Sellares and B Sis. American Journal of Transplantation 2010;10:2215-2222
 
Fundamental Concepts Regarding Graft Injury and Regeneration: Tissue Injury, Tissue Quality, and Recipient Factors. C Kreepala, KS Famulski and PF Halloran. Textbook of Organ Transplantation, First Edition. Edited by AD Kirk, SJ Knectle, CP Larsen, TC Pearson and JC Madsen. © 2013 John Wiley & Sons, Ltd. Published 2013 by John Wiley & Sons, Ltd., Chapter 10, pp 99-118
  

Human PBTs: kidney and inflammatory cells

Core PBT List (HG U133_2.0_plus arrays) U133 Core PBTs.xlsx
Core PBT List (HG U219 arrays) U219 Core PBTs.xlsx

 

Human PBTs: cardiac injury and cardiac associated; HG U133_2.0_plus arrays 

Cardiac injury and cardiac associated transcripts cIRIT HT.xlsx
   

Mouse PBTs; MG 430_2.0 arrays

CTL associated transcripts mCATs.xls
True gamma IFN and rejection induced transcripts mtGRITs.xls
Occult gamma IFN and rejection induced transcripts moGRITs.xls
Gamma-IFN suppressed transcripts mGSTs.xls
Alternative Macrophage Activation Transcripts mAMATs.xls
Class I-suppressed transcripts mCISTs.xls
Injury and repair induced transcripts mIRITs.xls
Renal transcripts mRTs.xls
Solute Carriers mSlcs.xls